What is DHEA-S Test?
The DHEA-S (Dehydroepiandrosterone sulfate) test measures the level of DHEA-S, a hormone produced by the adrenal glands. DHEA-S is a precursor to sex hormones like testosterone and estrogen. This test helps evaluate adrenal gland function, investigate hormonal imbalances and diagnose conditions like polycystic ovary syndrome (PCOS), adrenal tumors or congenital adrenal hyperplasia.
How is the Test Performed?
A blood sample is drawn from the patient, usually from the arm. It is then analyzed in the lab for the DHEA-S hormone. In some cases fasting may be required, instructions for which will be given by your healthcare provider.
What are the symptoms that prompt this test?
DHEA-S levels need to be in the optimal range. Low or high levels of DHEA-S can cause the following symptoms:
Male
- Low libido or sex drive
- Infertility
- Unexplained fatigue
- Loss of muscle mass
Females
- Irregular menstrual cycles
- Excess facial or body hair
- Severe acne
- Unexplained infertility
Children
- Early puberty signs in boys
- Development of masculine traits in girls
- Growth abnormalities
- Excessive body odor
What are Normal Ranges for This Test?
Males
80 to 560 μg/dL (varies with age)
Females
35 to 430 μg/dL (varies with age)
**The above-given reference value is for general guidelines only. Your healthcare provider will give you the correct interpretation of the results. **
What Happens if Test Results Show Abnormal Levels?
Abnormal DHEA-S levels may indicate:
High Levels – Could suggest PCOS, adrenal tumors or Cushing’s syndrome.
Low Levels – May point to Addison’s disease, hypopituitarism or adrenal insufficiency.
Additional tests like cortisol levels, ACTH stimulation test or imaging studies (CT/MRI) to investigate the underlying cause.
