Coomb's Test (Indirect)
Detect Antibodies In Blood
Disease.
Female Fertility Tests
Department.
Hematology
TAT.
1 Day
Sample Type
- 2 mL (1 mL min.) serum from 1 SST.
What Is ICT Test?
The Indirect Coombs Test (ICT) also known as Indirect Antoglobulin Test (IAT) is a blood test that detects antibodies in plasma that may target red blood cells. The test is essential in assessing blood compatibility before transfusions, diagnosing hemolytic diseases in newborns and identify autoimmune conditions that affect RBCs.
ICT is a common test that is performed with pregnant women to check Rh incompatibility, a condition where the mother’s immune system attacks the red blood cells of the fetus, if their blood types are incompatible. ICT is also a vital screening process before blood transfusion to ensure blood types are compatible, preventing hemolytic reactions. ICT helps healthcare providers prevent serious immune responses that could lead to anemia or other medical complications. It is also important in blood bank operations to store blood.
How is the Test Performed?
Sample Collection
The test requires a blood sample drawn from a vein of the patient.
Lab Testing
The blood sample is mixed with reagent red blood cells that contain specific antigens. If antibodies are present in the plasma, they will attach to these reagent RBCs. After adding Coombs reagent (anti-human globulin), the test identifies whether agglutination (clumping) occurs. The presence of agglutination indicates a positive ICT, meaning antibodies are present.
What are the symptoms that prompt this test?
The test is ordered if a patient shows the following symptoms:
- Fatigue and weakness
- Unexplained jaundice (yellowing of skin and eyes)
- Dark-colored urine
- Shortness of breath
- Rapid heart rate
- Unusual bruising or prolonged bleeding
- Persistent anemia despite treatment
- Unexplained fever
- Delayed growth or development
- Lethargy and weakness
- Swelling in the limbs
- Routine prenatal screening for Rh incompatibility during pregnancy
- History of previous miscarriages or stillbirths
What are Normal Ranges for This Test?
Men – A negative ICT result indicates the absence of harmful antibodies.
Women – A negative ICT result is normal, while a positive result suggests Rh incompatibility or another immune reaction.
**The above mentioned range is for information purpose only. Normal levels are dependent on how the test is conducted. Result interpretation should be done by a qualified doctor or healthcare professional.**
What Happens if Test Results Show Abnormal Levels?
If the ICT result is positive, further evaluation is required to determine the cause of antibody presence. Your doctor may order:
- Direct Coombs Test (DCT) to check if antibodies are attacking the patient’s RBCs.
- Repeat ICT Testing to monitor antibody levels over time.
- Hemolysis Blood Tests, including bilirubin and lactate dehydrogenase (LDH) tests, to assess RBC destruction.
- Ultrasound for Pregnant Women to check fetal well-being in cases of Rh incompatibility.
- Blood Matching & Crossmatching Tests before transfusion to ensure compatibility.
Why Choose Genex?
State Of The Art Technology
We use advanced technology and equipment to ensure precise and reliable results. Our cutting-edge tools and methodologies guarantee the highest standards of lab testing.
Highly Skilled Team
Our team consists of skilled technicians trained to handle complex hormonal tests with high accuracy. Each member has years of experience & specialized knowledge to every test.
Fast Turnaround Time
Get your results quickly, helping to make timely decisions regarding your health. We understand the importance of prompt information for effective health management.
Patient-Centered Care
Genex Lab prioritizes your comfort and satisfaction throughout the testing process. Our compassionate approach ensures a supportive and reassuring experience for patients.
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